Research News

Stem-cell biologist Mahendra Rao has resigned as director of the NIH Center for Regenerative Medicine.

NIH closes stem-cell research program after funding one project, journal reports

Stem-cell researchers at the National Institutes of Health (NIH) are frustrated and confused following the demise of the agency’s Center for Regenerative Medicine (CRM), according to a story published April 8 in Nature science journal.

The program’s director, stem-cell biologist Mahendra  read more…

Gordon L. Snider, MD and widow Sally Everett

Alpha-1 Foundation invites applications for Gordon L. Snider Scholar Award

The Alpha-1 Foundation is accepting applications for a new research grant, the Gordon L. Snider Scholar Award.

The award is named after Gordon L. Snider, MD, one of the most influential researchers in Alpha-1. Snider not only made seminal scientific contributions  read more…

An artist's illustration of lung cancer cells among healthy air sacs. By David Mack/Science Source.

Blood test to detect early
lung cancer getting closer

One of these days there could well be a simple blood test that can help diagnose and track cancers. We aren’t there yet, but a burst of research in this area shows we are getting a lot closer.

In the latest  read more…

Royalty-Free Stock Photography by Rubberball

Kamada enrolling participants in study of Alpha-1 to treat transplant-related disease

Kamada biotherapeutics company on Thursday announced a U.S.-based study with Glassia, its Alpha-1 therapy, to treat graft-versus-host disease (GVHD).

The Phase 1/2 study, now enrolling participants, will be conducted in cooperation with Baxter International at the Fred Hutchinson Cancer Research Center in Seattle,  read more…

circadian rhythm

Study: Timing to circadian rhythm may improve asthma, COPD therapies

The body clock’s natural rhythm could be used to improve therapies to delay the onset of chronic lung diseases.

Scientists at The University of Manchester, England, say they have discovered a rhythmic defense pathway in the lung controlled by our body  read more…

The eFlow device is used to deliver inhaled alpha-1 therapy.

Kamada announces U.S. trial of inhaled therapy to treat Alpha-1

Kamada biotherapeutics company on Monday announced the start of a new Phase 2 U.S. clinical trial of its inhaled alpha-1 antitrypsin (AAT) therapy for the treatment of Alpha-1 Antitrypsin Deficiency.

The trial is a double-blind, placebo-controlled study evaluating the safety and  read more…

lung

FDA panel approves device to improve lung transplant success

A Food and Drug Administration advisory committee gave unanimous approval March 20 to a device to improve the quality of donor lungs using warm perfusion after removal from the donor.

The panel said there was reasonable assurance that XVIVO XPS perfusion  read more…

stem-cell-research

Results announcement delayed in clinical trial of Kamada’s inhaled Alpha-1 therapy

Kamada biotherapeutics company said Friday that it expects to report data from the pivotal Phase 2/3 clinical trial in Europe and Canada of its inhaled Alpha-1 therapy by the end of April or the beginning of May. Previously, Kamada  read more…

asthma

Several firms working to develop injectable biotech drugs for people with severe asthma

A handful of companies are racing to develop injectable biotech asthma drugs for patients with severe disease who don’t respond well to traditional inhalers.

GlaxoSmithKline, the leader in asthma treatments since launching its Ventolin inhaler in 1969, is in the vanguard  read more…

Image of a stem cell.

Alpha-1 researcher, others had questioned stem-cell findings, retracted for ‘crucial mistakes’

The co-author of two breakthrough papers on making stem cells said Monday he had asked for the papers to be retracted, citing “crucial mistakes” in the research.

The decision is the latest and perhaps heaviest blow against the research, which was  read more…

Closeup of a stem cell.

Study shows ability to make mature, functioning liver cells from skin cells

There have been several reports in recent years of scientists reprogramming skin cells so they transform into cells that are similar to cells from other organs, such as the heart, the pancreas and even brain cells. However, these have fallen  read more…

Victor Dzau

Institute of Medicine names
Dzau as its new president

Duke University Health System President and CEO Victor Dzau, MD, was named president of the Institute of Medicine (IOM), succeeding longtime president Harvey Fineberg, MD, the National Academy of Sciences announced Wednesday.

The Institute of Medicine (IOM) is an independent, nonprofit organization that works  read more…

Researchers grew a human lung, white because there is no blood in it, in an aquarium.

Researchers grow human lungs in lab for first time, offering promise in transplants

More than 1,600 people are on the waiting list for a lung transplant. Now, scientists at University of Texas Medical Branch (UTMB) in Galveston have come up with something that will give them hope. For the first time, scientists have  read more…

stem-cell-research

The Alpha-1 Project funding PhD fellowship at NIH; applications due by April 30

The Alpha-1 Project (TAP), the venture philanthropy arm of the Alpha-1 Foundation, on Wednesday announced it will fund a two-year postdoctoral fellowship position at the National Institutes of Health’s (NIH) National Center for Advancing Translational Sciences (NCATS).

Qualified applicants must hold a  read more…

lung

Irish study proves that MZ carriers who smoke are at higher risk of COPD

One in 25 people in Ireland are at risk of developing chronic obstructive pulmonary disease (COPD) due to a combination of inherited genes and exposure to cigarette smoke, a new study says.

The study, by researchers from the Alpha One Foundation Ireland,  read more…

John Walsh, left, presents Steve Groft with crystal candlesticks in recognition of how Groft 'lit the way' for the rare disease community.

Retiring rare disease pioneer honored at Foundation clinical trial design meeting

The Alpha-1 Foundation brought together members of the medical community, researchers, patient advocates, and government and pharmaceutical industry representatives for the meeting “Clinical Trial Design for Alpha-1 Deficiency: A Model for Rare Diseases,” held Feb. 3-4 in Bethesda, MD.

The focus  read more…

clinical trials

FDA considers faster approval for high-need devices, urges broadening study participation

The U.S. Food and Drug Administration (FDA) wants to create an expedited approval pathway for high-risk medical devices for unmet needs, saying current tools at its fingertips are ineffective for speedier approvals.

The change the agency is considering would create more  read more…

Alpha-1 researcher Darrell Kotton, MD, who does stem cell research at the Center for Regenerative Medicine at Boston University School of Medicine, calls the findings 'potentially paradigm-shifting, but also perplexing.'

Alpha-1 researcher calls new stem cell findings ‘exciting, perplexing’

In experiments that could open a new era in stem cell biology, scientists have found a simple way to reprogram mature animal cells back into an embryonic-like state that allows them to generate many types of tissue.

The new work reveals  read more…

clinical trials

Institute of Medicine solicits ideas on wider sharing of clinical trials data

The Institute of Medicine is soliciting comment on how best to responsibly share data from clinical trials.

The institute has issued a discussion framework that includes preliminary guiding principles, defined selected data, data sharing activities and specific questions for researchers,  read more…

Royalty-Free Stock Photography by Rubberball

TAP partners with investment firm Poliwogg to seek new ways to fund Alpha-1 research

The Alpha-1 Project (TAP) on Monday announced a partnership with Poliwogg, a financial innovation firm creating new ways to invest in health companies.

“We continue to incorporate creative and useful tools … to help finance and support our industry partners,” said  read more…