Research News

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The Alpha-1 Foundation announces
2014-15 grant funding opportunities

Members of the medical, research and scientific communities are invited bring the cure for Alpha-1 Antitrypsin Deficiency within reach by participating in the Alpha-1 Foundation’s research programs.

Get complete information about our research opportunities, application deadlines, application forms and letter of  read more…

A supercooled rat liver sits in the preservation solution in the machine perfusion system. The blue color is caused by antifreeze that surrounds the components of the system to regulate the temperature.

In NIH study, researchers use supercooling technique to preserve liver for transplant

Researchers have developed a new supercooling technique to increase the amount of time human organs could remain viable outside the body. This study was conducted in rats, and if it succeeds in humans, it would enable a world-wide allocation of  read more…

research

What’s new in Alpha-1 research: vitamin D, a fellowship, a better Research Registry

This week, the Alpha-1 Foundation sent an update on top research news to more than 900 members of the scientific and medical community. Current research-related news the Foundation is highlighting:

Know a brilliant young researcher?
Check out TAP-NCATS fellowship

The Alpha-1 Project (TAP),  read more…

lung

Institute launches lung cancer treatment program; lawmakers urge Medicare pay for CT scan

The National Cancer Institute (NCI) is teaming up with biopharmaceutical companies and patient advocates on a clinical trial program that aims to use genomic profiling to match squamous cell lung cancer patients to treatments based on their individual cancer profiles.

The program, dubbed the Lung Master Protocol  read more…

idiopathic_pulmonary_fibrosis

Two experimental drugs found to slow decline in idiopathic pulmonary fibrosis patients

For the first time, researchers have found drugs that can slow the decline of people with a fatal lung disease, idiopathic pulmonary fibrosis.

Studies of two experimental drugs  read more…

Research poster design

Kamada announces preliminary results of inhaled Alpha-1 therapy clinical trial

Kamada biotherapeutics company on Friday announced preliminary results from its Phase II/III pivotal clinical trial in Europe and Canada of its inhaled augmentation therapy for treating Alpha-1 Antitrypsin Deficiency.

The trial used alpha-1 protein (AAT) inhaled using a nebulizer, and early results  read more…

liver

Five-year study of Alpha-1 liver disease in adults now enrolling

A five-year, multi-center study of Alpha-1 liver disease in adults has enrolled its first participants and is actively recruiting Alphas to take part, says Alpha-1 researcher Jeffrey Teckman, MD, of the Saint Louis University School of Medicine, who is the study’s  read more…

Stem-cell biologist Mahendra Rao has resigned as director of the NIH Center for Regenerative Medicine.

NIH closes stem-cell research program after funding one project, journal reports

Stem-cell researchers at the National Institutes of Health (NIH) are frustrated and confused following the demise of the agency’s Center for Regenerative Medicine (CRM), according to a story published April 8 in Nature science journal.

The program’s director, stem-cell biologist Mahendra  read more…

Gordon L. Snider, MD and widow Sally Everett

Alpha-1 Foundation invites applications for Gordon L. Snider Scholar Award

The Alpha-1 Foundation is accepting applications for a new research grant, the Gordon L. Snider Scholar Award.

The award is named after Gordon L. Snider, MD, one of the most influential researchers in Alpha-1. Snider not only made seminal scientific contributions  read more…

An artist's illustration of lung cancer cells among healthy air sacs. By David Mack/Science Source.

Blood test to detect early
lung cancer getting closer

One of these days there could well be a simple blood test that can help diagnose and track cancers. We aren’t there yet, but a burst of research in this area shows we are getting a lot closer.

In the latest  read more…

Royalty-Free Stock Photography by Rubberball

Kamada enrolling participants in study of Alpha-1 to treat transplant-related disease

Kamada biotherapeutics company on Thursday announced a U.S.-based study with Glassia, its Alpha-1 therapy, to treat graft-versus-host disease (GVHD).

The Phase 1 and 2 study, now enrolling participants, will be conducted in cooperation with Baxter International at the Fred Hutchinson Cancer Research  read more…

circadian rhythm

Study: Timing to circadian rhythm may improve asthma, COPD therapies

The body clock’s natural rhythm could be used to improve therapies to delay the onset of chronic lung diseases.

Scientists at The University of Manchester, England, say they have discovered a rhythmic defense pathway in the lung controlled by our body  read more…

The eFlow device is used to deliver inhaled alpha-1 therapy.

Kamada announces U.S. trial of inhaled therapy to treat Alpha-1

Kamada biotherapeutics company on Monday announced the start of a new Phase 2 U.S. clinical trial of its inhaled alpha-1 antitrypsin (AAT) therapy for the treatment of Alpha-1 Antitrypsin Deficiency.

The trial is a double-blind, placebo-controlled study evaluating the safety and  read more…

lung

FDA panel approves device to improve lung transplant success

A Food and Drug Administration advisory committee gave unanimous approval March 20 to a device to improve the quality of donor lungs using warm perfusion after removal from the donor.

The panel said there was reasonable assurance that XVIVO XPS perfusion  read more…

stem-cell-research

Results announcement delayed in clinical trial of Kamada’s inhaled Alpha-1 therapy

Kamada biotherapeutics company said Friday that it expects to report data from the pivotal Phase 2/3 clinical trial in Europe and Canada of its inhaled Alpha-1 therapy by the end of April or the beginning of May. Previously, Kamada  read more…

asthma

Several firms working to develop injectable biotech drugs for people with severe asthma

A handful of companies are racing to develop injectable biotech asthma drugs for patients with severe disease who don’t respond well to traditional inhalers.

GlaxoSmithKline, the leader in asthma treatments since launching its Ventolin inhaler in 1969, is in the vanguard  read more…

Image of a stem cell.

Alpha-1 researcher, others had questioned stem-cell findings, retracted for ‘crucial mistakes’

The co-author of two breakthrough papers on making stem cells said Monday he had asked for the papers to be retracted, citing “crucial mistakes” in the research.

The decision is the latest and perhaps heaviest blow against the research, which was  read more…

Closeup of a stem cell.

Study shows ability to make mature, functioning liver cells from skin cells

There have been several reports in recent years of scientists reprogramming skin cells so they transform into cells that are similar to cells from other organs, such as the heart, the pancreas and even brain cells. However, these have fallen  read more…

Victor Dzau

Institute of Medicine names
Dzau as its new president

Duke University Health System President and CEO Victor Dzau, MD, was named president of the Institute of Medicine (IOM), succeeding longtime president Harvey Fineberg, MD, the National Academy of Sciences announced Wednesday.

The Institute of Medicine (IOM) is an independent, nonprofit organization that works  read more…

Researchers grew a human lung, white because there is no blood in it, in an aquarium.

Researchers grow human lungs in lab for first time, offering promise in transplants

More than 1,600 people are on the waiting list for a lung transplant. Now, scientists at University of Texas Medical Branch (UTMB) in Galveston have come up with something that will give them hope. For the first time, scientists have  read more…